Omega-3s, vitamin D and magnesium

Taking EPA/DHA omega-3s, vitamin D, and magnesium together. A common combination used with the aim of supporting cardiovascular, bone, and general health; forms and doses vary.

Quick facts

  • 1Omega-3s (EPA and DHA) and vitamin D are the two most widely taken longevity-adjacent supplements.
  • 2Large trials like VITAL showed mostly neutral primary results with interesting subgroup signals for both.
  • 3Vitamin D status depends heavily on latitude, season and sun exposure; testing beats guessing.
  • 4Fat-soluble compounds absorb better with meals.

Why people do it

  • Covers common gaps: Low fish intake and indoor northern living make these the two most defensible defaults.

  • Cardio and inflammation interest: Omega-3 research on triglycerides is solid; broader cardiovascular findings are mixed but active.

  • Bone and immune roles: Vitamin D's core physiology is uncontroversial even where supplement trials disappoint.

Good to know

  • Not medical advice: Supplement responses and interactions are individual; people typically review their stack with a clinician, especially alongside medication.

  • Quality varies: Third-party tested brands matter in a loosely regulated market.

Common questions

Should I test vitamin D first?+

The longevity crowd generally tests before and after rather than dosing blind; levels vary enormously.

Fish oil quality matters?+

Yes: oxidation is the known issue, so fresh, tested brands and refrigeration are the practice.

Takeaway

The default stack of the longevity world: sensible gap-covering with honest, mixed trial evidence. Test, take with food, review annually.

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For information only.

These habits are compiled from public statements and are not medical advice or endorsed by Peter Attia. Consult a qualified professional before changing your routine, supplements, or therapies.